The 30-stock BSE index finished 465.01 points or 0.95% lower to 48,253.51, and the larger NSE Nifty fell 137.65 points or 0.94% to 14,496.50.

The Sensex market benchmark fell 465 points on Tuesday, following the losses of index heavyweights Reliance Industries, the HDFC twins and Infosys despite a positive trend in global equities.

The 30-stock BSE index finished 465.01 points or 0.95% lower to 48,253.51, and the larger NSE Nifty fell 137.65 points or 0.94% to 14,496.50.

Dr Reddy’s was the first loser in the Sensex pack, losing around 2%, followed by Reliance Industries, Sun Pharma, the HDFC twins, Infosys, M&M and PowerGrid.

On the other hand, ONGC, Bajaj Finance, TCS, Nestlé India and SBI were among the winners.

“Domestic stocks gave up their gains towards the second half of the day and fell sharply as growing uncertainty over the rise of the second wave of COVID-19 cases weighed on investor sentiment,” said Binod Modi, Head of Strategy at Reliance Securities.

With the exception of PSU banks, selling pressure was visible in all sectors, with the pharmaceutical sector experiencing a sharp correction.

While a persistent increase in the daily caseload in several states is still a cause for concern, a visible slight drop in new cases in many areas like Maharashtra and Delhi offers comfort, he noted.

Active COVID-19 cases in India rose to 34,47,133 from 34,13,642 on Monday, according to an update from the Ministry of Health on Tuesday morning.

Elsewhere in Asia, the Hong Kong and Seoul stock exchanges ended on a positive note. The Shanghai and Tokyo stock exchanges were closed for the holidays.

Stocks in Europe were trading largely with gains in mid-session trades.

Meanwhile, international benchmark Brent crude was trading 1.79% higher at $ 68.77 per barrel.

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