In what can be considered encouraging news, the results of a new study suggest that a single dose of COVID-19 vaccine may be effective against mutant variants in people previously infected. the study, Posted in Science magazine, was conducted by a team of scientists from various universities and institutes in London, including Imperial College, University College, University of Nottingham, et al.
Conducted with healthcare workers who received the Pfizer / BioNTech vaccine, the study examined how the vaccine generated an immune response in those who were previously infected with the COVID-19 virus and those who were not infected. In particular, the study aimed to check whether vaccination and a previous infection correlated with the immune response against the mutant strains. He observed that after a dose of the vaccine, those who were previously infected had an immune response against variants B.1.1.7 (originally appeared in the UK) and B.1.351 (originating in South Africa).
More importantly, the study found that T cell immunity, B cell secreting antibodies, and neutralizing antibodies were enhanced in people previously infected and given a dose of the Pfizer / BioNTech vaccine. T cells and B cells are specialized cells that are part of the body’s immune system or defense mechanism and are programmed to fight infection.
Even though the study only considered two variants, the researchers believe the case may be true for other variants as well, for example those that originally emerged in India or Brazil.
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Commenting on the results, Rosemary Boyton, professor of immunology and respiratory medicine at Imperial College London, who led the research, was cited as herying That, “Our results show that people who received their first dose of vaccine and who have never been infected with SARS-CoV-2 are not fully protected against circulating variants of concern.”
“This study highlights the importance of implementing second doses of the vaccine to protect the population,” she added.
Among health care workers who have been infected previously, administration of a single dose of the vaccine resulted in a decrease in the level of neutralizing antibodies against the original strain and mutant variants. This indicates the importance of a second dose of the vaccine.
“Our data show that natural infection on its own may not provide sufficient immunity against the variants. Stimulation with a single dose of vaccine in people who have had an infection in the past probably does. As new variants continue to emerge, it is important to accelerate the global deployment of vaccines to reduce transmission of the virus and remove opportunities for new variants, ”added Boyton. Explaining the results of the study and its importance.
The study’s authors indicate what a future results-based perspective might be. “In the future, it will be important to resolve the quantitative and qualitative differences between these groups in terms of the repertoire of neutralizing antibodies as well as the phenotype and durability of B and T memory cell responses. The durability of immunity against natural and post-vaccination infections, as well as sustained vaccine efficacy and vaccine leakage should be monitored over time ”. report in Science Noted.